Structural elements in the Gag polyprotein of feline immunodeficiency virus involved in Gag self-association and assembly

Abstract

The Gag polyprotein of feline immunodeficiency virus (FIV) assembles at the plasma membrane of the infected cells. Since the FIV Gag domains whose interaction promotes Gag multimerization have not been identified, we generated a series of Gag subdomains which were tested for their ability to associate with full-length Gag and be recruited into extracellular virus-like particles (VLPs).